CZechMS.org - CMSC - Presentation Abstract

CMSC - Presentation Abstract

(13^th Czech Mass Spectrometry Conference and 11^th Informal Proteomic Meeting - WeO-01)
Towards MS-guided Precision Environmental Health: the Czech node of the European Research Infrastructure for Human Exposome Research

Elliott James Price ^1,2^*, Jana Klánová ^1,2

RECETOX, Facutly of Science, Masaryk University, Brno, Czechia
EIRENE-CZ, Czech node of the European Infrastructure for Human Exposome Research

Abstract

Understanding the molecular determinants of health and disease is essential for advancing precision prevention and treatment. Yet, the current availability of high-throughput assays for quantifying broad panels of clinically relevant proteins, metabolites, and environmental chemicals remains limited. The European Infrastructure for Human Exposome Research (EIRENE) is addressing this challenge by building a harmonized network of laboratories, population cohorts, environmental studies, and databases to elucidate how environmental exposures contribute to chronic disease.
This presentation introduces the mass spectrometry (MS) resources developed within the Czech node of EIRENE (EIRENE-CZ). These resources are designed to enable: (i) population-scale profiling of human exposure to environmental chemicals, (ii) quantitative analysis of clinically relevant protein and metabolite biomarkers, and (iii) high-throughput processing of MS data.
A suite of targeted MS assays has been established for the absolute quantification of biomarkers defined at the intersection of the Hallmarks of Health and Hallmarks of Environmental Insults frameworks. We shall report on applications to clinical research studies, evaluation compared to alternative clinical measurement approaches, and welcome input to prioritise key biomarkers and guide future assay development.
In parallel, LC- and GC-HRMS workflows for population-scale chemical exposure profiling have been implemented, and ongoing applications in cohort studies will be highlighted. We will reflect on current technological limitations and prospects for an international precision environmental health monitoring network.

* Corresponding author: elliott.price@recetox.muni.cz

References

https://doi.org/10.1016/j.isci.2022.103976
https://doi.org/10.1016/j.envint.2024.108585

Acknowledgement:

The research has been conducted within the European Infrastructure for Human Exposome Research (EIRENE RI), in cooperation with the Network of Exposomics in the US (NEXUS) and within the collaborative framework of the International Human Exposome Network (IHEN; HEU programme grant agreement 101137317). The authors acknowledge the EU’s H2020 grant agreements 857560 (CETOCOEN Excellence); the HEU grant agreements 101079789 (EIRENE PPP); and the RECETOX Research Infrastructure (LM2023069) financed by the MEYS (CZ.02.1.01/0.0/0.0/17_043/0009632). The views expressed are those of the author(s) and do not necessarily reflect those of the EU or REA.