Česká společnost pro hmotnostní spektrometrii

(Česká konference hmotnostní spektrometrie 2021 - PL-01)
Tau regulates access to microtubules

Zdeněk Lánský ^1 *

1. Institute of Biotechnology of the CAS, Prague, Czech Republic

Abstrakt

Tau is an intrinsically disordered microtubule-binding protein involved in a number of neurodegenerative diseases. Malfunction of tau and its detachment from axonal microtubules are correlated with axonal degeneration. However, mechanistic understanding of this process is still missing. We recently showed that tau molecules cooperatively form cohesive, selectively permeable, envelopes on the microtubule surface. Importantly, these tau envelopes can protect microtubules from microtubule-degrading enzymes. I will discuss the mechanism of the tau envelope formation and the roles of canonical neurodegeneration-related factors on the tau envelope dynamics.

* Korespondující autor: zdenek.lansky@ibt.cas.cz